maandag 23 februari 2009

Inevitable suicide.


During his studies on Caernorhabditis elegans, Sulston observed that some cells die during the larval development, from 1090 somatic cells in the larval stage to 959 in the adult hermaphrodite. This phenomenon is called Apoptosis in which the cell nucleus becomes condensed, the cell itself shrivels and the shrunken corps is rapidly engulfed and digested by neighboring cells. Apoptosis, or programmed cell death, is a highly regulated process that allows a cell to self-degrade in order for the body to eliminate unwanted or dysfunctional cells. Normal cell deaths are thought to be “suicides” in which the cell activates a death programme and kills itself, which is very essential in generating an individual with the right cell types in the right numbers and places as evidenced by loss of tail by the tadpoles during frog metamorphosis and shaping of human limbs where cells in the hands die creating the gaps between the fingers and toes. Unlike necrosis, where the cell dies by swelling and bursting its content in the area, which causes an inflammatory response, apoptosis is a very clean and controlled process where the content of the cell is kept strictly within the cell membrane as it is degraded. Programmed cell death is a regular feature of normal animal development and is probably the fate of a substantial fraction of cells produced in most animals including me and you.

2 opmerkingen:

  1. Hi Julius Kibugi,

    Very nice blog, I enjoyed reading it.
    Your title really caught the reader’s attention, the opening sentence on the other hand was rather a short introduction than a topic sentence.
    In the following sentences you positively switch a lot between making the comparison with another similar effect and examples for both effects. Most of your examples are human related which gives the reader more feeling with your blog. Your final sentence is a good summary of the previous lines and the ‘me and you ‘ makes the reader realize he is part of it...

    Good job
    Matthias

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  2. During his studies on Caernorhabditis elegans, Sulston observed that some cells die during the larval development, from 1090 somatic cells in the larval stage to 959 in the adult hermaphrodite. This phenomenon is called Apoptosis in which the cell nucleus becomes condensed, the cell itself shrivels and the shrunken corps is rapidly engulfed and digested by neighboring cells. Apoptosis, or programmed cell death, is a highly regulated process that allows a cell to self-degrade in order for the body to eliminate unwanted or dysfunctional cells. Normal cell deaths are thought to be “suicides” in which the cell activates a death programme and kills itself, which is very essential in generating an individual with the right cell types in the right numbers and places [add a comma here] as evidenced by loss of tail by the [no article here] tadpoles during frog metamorphosis and [by the- increases flow by clearly marking where it fits in the sentence] shaping of human limbs where cells in the hands die creating the gaps between the fingers and toes. Unlike necrosis, where the cell dies by swelling and bursting its content in the area, which causes an inflammatory response, apoptosis is a very clean and controlled process where the content of the cell is kept strictly within the cell membrane as it is degraded. Programmed cell death is a regular feature of normal animal development and is probably the fate of a substantial fraction of cells produced in most animals including me and you.

    I can agree with Matthias: interesting read and good link with the audience. Sometimes there's too much information in one sentence, which slows down reading and decreases flow.

    well done,

    olaf

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